Related Experiment Video

Updated: Apr 16, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

17.5K

Primary Immunodeficiency Diseases: An Opportunity in Pediatrics for Improving Patient Outcomes

Vivian P Hernandez-Trujillo1, Chris Scalchunes2, Hillary S Hernandez-Trujillo3

  • 1Miami Children's Hospital, Miami, FL, USA vivian.hernandez-trujillo@mch.com.

Clinical Pediatrics
|March 18, 2015
PubMed

Insights

Pediatricians show gaps in recognizing and diagnosing primary immunodeficiency diseases (PIDD), despite efforts to screen patients. Improved understanding of PIDD is crucial for earlier diagnosis and better patient outcomes.

Area of Science:

  • Immunology
  • Pediatrics

Background:

  • Primary immunodeficiency diseases (PIDD) stem from inherent immune system deficits, leading to increased susceptibility to infections.
  • Early and accurate diagnosis of PIDD is critical for improving patient prognosis and management.

Purpose of the Study:

  • To assess pediatricians' understanding, recognition, and diagnostic capabilities regarding PIDD.
  • To identify areas for improvement in PIDD diagnosis and management within general pediatrics.

Main Methods:

  • A mail survey was distributed to a sample of pediatricians.
  • Survey responses were compared with data from a similar survey of allergy and immunology specialists.

Main Results:

  • 35% of pediatricians reported discomfort with PIDD recognition and diagnosis.
  • Despite this, 95% ordered screening tests or referred patients, and 77% managed patients with PIDD.
  • A significant majority (84%) were unaware of existing professional guidelines for PIDD.

Conclusions:

  • Enhanced recognition of PIDD by pediatricians is essential for earlier diagnosis.
  • Optimizing ongoing therapy for patients with PIDD requires improved diagnostic skills among pediatricians.
Abstract

Keywords:
diagnosispediatricians’ knowledgeprimary immunodeficiencytreatment

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

3.0K
Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

8.2K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.6K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
87.9K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.5K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
505