Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.4K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.4K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.6K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.6K
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

470
Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
470
Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

976
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
976
Regulation of Food Intake01:30

Regulation of Food Intake

3.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges for cognitive research in spaceflight and analog environments.

iScience·2026
Same author

Phenylketonuria Alters the Prefrontal Cortex Genome-Wide Expression Profile Regardless of the Mouse Genetic Background.

Cells·2026
Same author

Targeting the dopaminergic midbrain in Alzheimer's disease: Therapeutic potential of focusing on specific neural circuits rather than single molecular pathways.

Neural regeneration research·2026
Same author

Norepinephrine and dopamine Imbalance in the medial frontal gyrus from patients with Alzheimer's disease.

IBRO neuroscience reports·2026
Same author

The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.

Molecular psychiatry·2025
Same author

GABAergic MicroRNA-34a in the Dorsal Raphe Nuclei Contributes to Circulating MicroRNA-34a Levels.

Molecular neurobiology·2025

Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.9K

When chocolate seeking becomes compulsion: gene-environment interplay.

Enrico Patrono1, Matteo Di Segni2, Loris Patella1

  • 1Department of Applied Clinical Science and Biotechnology, University of L'Aquila, Coppito, Italy.

Plos One
|March 18, 2015
PubMed
Summary
This summary is machine-generated.

Compulsive eating behavior is influenced by both genetics and environment. Low dopamine D2 receptor availability may be a genetic risk factor, with environmental stress altering receptor expression.

More Related Videos

A General Method for Evaluating Incubation of Sucrose Craving in Rats
12:44

A General Method for Evaluating Incubation of Sucrose Craving in Rats

Published on: November 4, 2011

14.0K
A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

8.0K

Related Experiment Videos

Last Updated: Apr 16, 2026

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.9K
A General Method for Evaluating Incubation of Sucrose Craving in Rats
12:44

A General Method for Evaluating Incubation of Sucrose Craving in Rats

Published on: November 4, 2011

14.0K
A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

8.0K

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Addiction Research

Background:

  • Eating disorders arise from complex gene-environment interactions.
  • Compulsive eating in response to stress is a hallmark of many eating disorders.

Purpose of the Study:

  • To investigate the gene-environment interplay in compulsive-like eating behavior.
  • To determine if low accumbal dopamine D2 receptor (D2R) availability is a genetic risk factor for compulsive eating.
  • To examine how environmental conditions alter D2R expression in the striatum.

Main Methods:

  • Compared compulsion-like eating in stressed C57BL/6J and DBA/2J mice.
  • Measured dopamine D1 and D2 receptor (D1R, D2R) expression in the striatum.
  • Assessed D1R, D2R, and alpha-1 adrenergic receptor (α1R) levels in the medial prefrontal cortex via western blot.

Main Results:

  • Environmental stress induced compulsion-like eating, influenced by genetic background.
  • This behavior correlated with decreased accumbal D2R availability.
  • Environmental conditions upregulated striatal D2R and downregulated medial prefrontal cortex α1R in compulsive mice.

Conclusions:

  • Gene-environment interplay significantly impacts compulsive eating.
  • Low accumbal D2R availability is a likely genetic risk factor.
  • Neuroadaptive changes in D2R and α1R may underlie the transition to compulsive eating.