Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Too big, too small, too O<sub>2</sub>: the Pandoro Effect from oxygen gradients in tomographic volumetric additive manufacturing.

Biofabrication·2026
Same author

TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER triage checkpoint for BMP4/Dpp.

Cell reports·2026
Same author

Overprinting with tomographic volumetric additive manufacturing.

Nature communications·2026
Same author

High-efficiency multi-scale holographic volumetric 3D printing with a phase light modulator.

Light, science & applications·2026
Same author

Biocompatible Self-Healing Hydrogel for VAT 3D Printing.

ACS materials Au·2026
Same author

Leveraging low index contrast to reduce the polarization anisotropy in one-dimensional photonic crystals.

Optics express·2026

Related Experiment Video

Updated: Apr 16, 2026

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy
08:27

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Published on: December 12, 2025

1.5K

Angularly resolved ellipsometric optical biosensing by means of Bloch surface waves.

Alberto Sinibaldi1, Aleksei Anopchenko, Riccardo Rizzo

  • 1Department of Basic and Applied Science for Engineering, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy.

Analytical and Bioanalytical Chemistry
|March 19, 2015
PubMed
Summary

This study introduces advanced optical sensors using photonic crystals and Bloch surface waves for highly sensitive, label-free biosensing. The technology achieves a low limit of detection, enabling early cancer biomarker identification.

More Related Videos

Author Spotlight: Characterizing Environmental Biofilm Mechanics Using Optical Coherence Elastography and its Applications in Wastewater Treatment
04:51

Author Spotlight: Characterizing Environmental Biofilm Mechanics Using Optical Coherence Elastography and its Applications in Wastewater Treatment

Published on: March 1, 2024

1.6K
Evanescent Field Based Photoacoustics: Optical Property Evaluation at Surfaces
10:21

Evanescent Field Based Photoacoustics: Optical Property Evaluation at Surfaces

Published on: July 26, 2016

12.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy
08:27

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Published on: December 12, 2025

1.5K
Author Spotlight: Characterizing Environmental Biofilm Mechanics Using Optical Coherence Elastography and its Applications in Wastewater Treatment
04:51

Author Spotlight: Characterizing Environmental Biofilm Mechanics Using Optical Coherence Elastography and its Applications in Wastewater Treatment

Published on: March 1, 2024

1.6K
Evanescent Field Based Photoacoustics: Optical Property Evaluation at Surfaces
10:21

Evanescent Field Based Photoacoustics: Optical Property Evaluation at Surfaces

Published on: July 26, 2016

12.1K

Area of Science:

  • Photonics
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Label-free biosensing requires improved detection limits for biomolecules.
  • Optical sensors are crucial for detecting subtle refractive index changes.

Purpose of the Study:

  • To develop and implement novel optical sensors for label-free biosensing.
  • To achieve a lower limit of detection for enhanced biomolecule sensing.

Main Methods:

  • Utilized one-dimensional photonic crystals supporting Bloch surface waves.
  • Implemented an angularly resolved ellipsometric optical sensing scheme.
  • Employed tantala/silica multilayers for Bloch surface wave sustentation.

Main Results:

  • Achieved an experimental limit of detection of 6.5 × 10⁻⁷ refractive index units (RIU)/Hz¹/².
  • Demonstrated the sensor's capability for detecting the cancer biomarker angiopoietin 2.
  • Reported the first practical application of this technique for cancer biomarker detection.

Conclusions:

  • The developed photonic crystal sensors offer a promising platform for highly sensitive label-free biosensing.
  • The technique enables the detection of specific glycoproteins involved in angiogenesis and inflammation.
  • Further improvements in the limit of detection are feasible with this sensor design.