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Updated: Apr 16, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Current and future applications of corneal cross-linking
Sumitra S Khandelwal1, J Bradley Randleman
1aBaylor College of Medicine, Cullen Eye Institute, Houston, Texas, USA bDepartment of Ophthalmology, Emory University cEmory Vision, Emory Eye Center, Atlanta, Georgia, USA.
Purpose Of Review:
To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis.
Recent Findings:
Several important laboratory and clinical studies have established the safety and success of corneal cross-linking for the treatment of keratoconus and other corneal ectasias. Recently, additional studies have analyzed new directions and controversies in corneal cross-linking, exploring new indications, comparing new techniques and analyzing results of new protocols.
Summary:
The results of bench and clinical research are providing the foundation to allow for protocol modifications of the standard cross-linking protocols and expansion of cross-linking concepts for techniques such as accelerated cross-linking, epithelium-sparing protocols and measurement of progression and success.
