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Updated: Apr 16, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Coffee, Genetic Variants, and Parkinson's Disease: Gene-Environment Interactions
Naomi Yamada-Fowler1, Peter Söderkvist1
1Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University , Linköping, Sweden .
Abstract:
Studies of gene-environment interactions may help us to understand the disease mechanisms of common and complex diseases such as Parkinson's disease (PD). Sporadic PD, the common form of PD, is thought to be a multifactorial disorder caused by combinations of multiple genetic factors and environmental or life-style exposures. Since one of the most extensively studied life-style factors in PD is coffee/caffeine intake, here, the studies of genetic polymorphisms with life-style interactions of sporadic PD are reviewed, focusing on coffee/caffeine intake.
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