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Updated: Apr 16, 2026
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Anaplastic thyroid carcinoma accompanied by uncontrollable eosinophilia
Jun Shiraishi1, Hidenori Koyama, Miwako Seki
1Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|March 20, 2015
Summary
This case report details an rare instance of anaplastic thyroid carcinoma (ATC) with severe, steroid-resistant eosinophilia. The patient
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Anaplastic thyroid carcinoma (ATC) is an aggressive endocrine malignancy.
- Eosinophilia, an elevated eosinophil count, is uncommon in ATC.
- This report focuses on a rare case of ATC with significant eosinophilia.
Observation:
- A 71-year-old male presented with end-stage ATC and marked, uncontrollable eosinophilia.
- The eosinophilia was refractory to standard steroid treatment.
- The patient experienced severe dyspnea and an allergic reaction to chemotherapy.
Findings:
- Serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) were analyzed.
- GM-CSF levels were moderately elevated.
- IL-3 and IL-5 levels remained within normal ranges, suggesting a complex etiology for the eosinophilia.
Implications:
- The etiology of eosinophilia in this ATC case remains unclear but may involve dyspnea and drug reactions.
- Understanding eosinophilia's cause is crucial for managing ATC patients.
- Further research is needed to improve treatment strategies for ATC with eosinophilia.
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