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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Related Experiment Video

Updated: Apr 16, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
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[Correlation between primary cilium and Wnt signaling pathway].

Man-Li Zhang1, Yan-Ping Lu1, Ya-Li Li1

  • 1Department of Gynaecology and Obstetrics, The PLA General Hospital,Beijing 100853, China.

Yi Chuan = Hereditas
|March 20, 2015
PubMed
Summary

Primary cilia act as cellular antennae, crucial for Wnt signaling in embryonic development. Their dysfunction disrupts this signaling, leading to ciliopathies, a group of diseases.

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Area of Science:

  • Cell Biology
  • Developmental Biology

Context:

  • Primary cilia are microtubule-based cellular antennae originating from the mother centriole.
  • They function as sensory organelles, detecting environmental signals and mediating cellular responses.
  • These cilia are vital for embryonic development, particularly through their role in Wnt signaling pathways.

Purpose:

  • To review the intricate relationship between primary cilia, Wnt signaling pathways (including Wnt/β-catenin and Wnt/planar cell polarity), and the pathogenesis of ciliopathies.
  • To discuss current therapeutic strategies for ciliopathies.
  • To highlight research directions for developing Wnt-associated diagnostic tools and treatments.

Summary:

  • Primary cilia are essential for Wnt signaling, which regulates embryonic development.
  • Primary cilia dysfunction leads to deregulated Wnt signaling and subsequent ciliopathies.
  • This review explores the links between primary cilia, Wnt signaling, and ciliopathies, alongside existing therapies.

Impact:

  • Understanding the role of primary cilia in Wnt signaling can lead to novel diagnostic approaches for ciliopathies.
  • This research may pave the way for targeted Wnt-associated therapies for these complex genetic disorders.
  • Highlights potential for developing specific Wnt-pathway modulators for treating ciliopathies.