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Updated: Apr 16, 2026

Chronic Constriction Injury of the Rat's Infraorbital Nerve IoN-CCI to Study Trigeminal Neuropathic Pain
Published on: September 21, 2015
Infratrochlear neuralgia
Juan A Pareja1, Ignacio Casanova2, Andrea Arbex3
1Neurology Department, University Hospital Quirón Madrid, Pozuelo de Alarcón, Madrid, Spain Neurology Department, University Hospital Fundación Alcorcón, Alcorcón, Madrid, Spain japareja@fhalcorcon.es.
Introduction:
The infratrochlear nerve supplies the medial aspect of the upper eyelid, the superolateral aspect of the nose and the lacrimal caruncle. This nerve may contribute to the pain stemming from the trochlea, but infratrochlear neuralgia has not been identified as a specific cause of pain.
Methods:
Over a 10-year period we have been recruiting patients with pain in the internal angle of the orbit that did not show features of trochlear pain.
Results:
Seven patients (six female, one male; mean age, 46.1 ± 18.9) presented with pain in the territory of the infratrochlear nerve. The pain appeared in the internal angle of the orbit and upper eyelid (n = 3), the superolateral aspect of the nose (n = 3), or the lacrimal caruncle (n = 1). All patients had a paroxysmal pain, with the attacks lasting five to 30 seconds. Pain attacks were mostly spontaneous, but two patients had triggers. Between attacks, all patients had local allodynia. Pain did not increase with vertical eye movements. Six patients were treated with gabapentin with complete response, and one patient experienced long-lasting relief with an anesthetic blockade of the infratrochlear nerve.
Conclusion:
Infratrochlear neuralgia should be considered as a possible cause of pain in the internal angle of the orbit.
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