Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ozanimod Reduces Serum Neurofilament Light Chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) and Modulates Innate and Adaptive Immunity in Patients with Low-to-Moderate Activity Relapsing-Remitting Multiple Sclerosis.

International journal of molecular sciences·2026
Same author

Behavioral barriers in the management of spinal muscular atrophy: The role of procrastination, regret, and burnout.

PloS one·2026
Same author

Benefits of a Perceived High-Intensity Exercise Program with Immersive Virtual Reality Combined with Usual Rehabilitation in Multiple Sclerosis: Exploratory Study.

Medicina (Kaunas, Lithuania)·2026
Same author

Personalizing Relapsing-Remitting Multiple Sclerosis Monitoring: Patient Acceptance of Serum Neurofilament Light Chain and the Role of Disease Knowledge.

Journal of personalized medicine·2026
Same author

Large language models as clinical decision-support tools in multiple sclerosis and neuromyelitis optica spectrum disorders: A comparative study of ChatGPT-4o and neurologists.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

HERV-W association with serum biomarkers NfL and GFAP in multiple sclerosis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jun 3, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Workplace difficulties in early-stage relapsing-remitting multiple sclerosis with low physical disability.

Ángel Pérez-Sempere1, Elena García-Arcelay2, Jacobo Caruncho3

  • 1Department of Neurology, Hospital Universitario General de Alicante, Universidad Miguel Hernández, Alicante, Spain.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|June 2, 2026
PubMed
Summary

Many individuals with early-stage multiple sclerosis (MS) face workplace challenges, primarily due to non-motor symptoms like fatigue and anxiety, not physical disability. Addressing these factors is crucial for maintaining employment and career progression.

Keywords:
Multiple sclerosisanxietyemploymentfatiguegender disparitywork difficulties

More Related Videos

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Neurology
  • Occupational Health
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) significantly impacts individuals' lives, often extending beyond physical limitations.
  • Early-stage relapsing-remitting MS (RRMS) with low physical disability can still present substantial workplace challenges.

Purpose of the Study:

  • To evaluate the perceived workplace difficulties in individuals with early-stage RRMS and low physical disability.
  • To identify predictors of workplace challenges in this population.

Main Methods:

  • A study involving 128 individuals with early-stage RRMS and low physical disability.
  • Utilized the 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) to assess workplace challenges.
  • Employed multivariable analysis to determine independent predictors of workplace difficulty.

Main Results:

  • 40.6% of participants reported significant workplace challenges.
  • External barriers, such as inflexibility and work-life imbalance, posed the greatest burden.
  • Fatigue (OR 1.37) and anxiety (OR 1.21) were identified as key independent predictors of workplace difficulty.
  • Women reported higher difficulty scores than men.

Conclusions:

  • Workplace vulnerability in early-stage MS is primarily driven by non-motor symptoms (fatigue, anxiety) rather than overt neurological impairment.
  • A dissociation exists between physical disability and functional work outcomes.
  • Proactive clinical screening for fatigue and anxiety is essential to support vocational stability and long-term career trajectories in individuals with MS.