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Odor-cued taste avoidance: a simple and robust test of mouse olfaction

Burton Slotnick1, David M Coppola2

  • 1Department of Psychology, American University, Washington DC, 20016, USA and slotnic@american.edu.

Chemical Senses
|March 20, 2015
PubMed
Summary

Mice rapidly learn to avoid unpleasant odors using odor-cued taste avoidance (OCTA). This simple conditioning procedure effectively assesses mouse olfaction, offering advantages over other methods.

Keywords:
mouse olfactionodor detectionolfactory test

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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...