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Open-access metabolomics databases for natural product research: present capabilities and future potential
Sean R Johnson1, Bernd Markus Lange1
1Institute of Biological Chemistry, M.J. Murdock Metabolomics Laboratory, Washington State University , Pullman, WA , USA.
Frontiers in Bioengineering and Biotechnology
|March 20, 2015
Summary
This review explores open-access spectral and chemical databases crucial for identifying natural product structures from metabolomics data. It offers insights for researchers to enhance these valuable resources.
Area of Science:
- Metabolomics
- Natural Products Chemistry
- Bioinformatics
Background:
- Metabolomics experiments generate complex spectral data requiring structural identification.
- Databases are essential tools for assigning chemical structures to observed spectral peaks.
- Open-access resources are vital for broad accessibility in scientific research.
Purpose of the Study:
- To review the utility of existing open-access spectral and chemical databases.
- To assess their application in natural products discovery.
- To provide recommendations for community-driven improvements.
Main Methods:
- Literature review of open-access spectral and chemical databases.
- Analysis of database applicability in natural products structure elucidation.
- Synthesis of current challenges and future directions.
Main Results:
- Identified key open-access databases relevant to metabolomics and natural products.
- Evaluated the strengths and limitations of current database resources.
- Highlighted the need for standardized data formats and expanded coverage.
Conclusions:
- Open-access databases significantly aid natural products discovery from metabolomics data.
- Community contributions are essential for enhancing database accuracy, scope, and usability.
- Future efforts should focus on data integration and improved search functionalities.
