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Updated: Apr 16, 2026
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Mortality hazard and survival after tuberculosis treatment
Thaddeus L Miller1, Fernando A Wilson, Jenny W Pang
1Thaddeus L. Miller is with the Department of Health Management and Policy, University of North Texas Health Science Center, Fort Worth. Stephen E. Weis is with the Department of Medicine, University of North Texas Health Science Center. Fernando A. Wilson is with the Department of Health Services Research & Administration, University of Nebraska Medical Center, Omaha. Jenny W. Pang is with the Department of Epidemiology, University of Washington School of Public Health, Seattle. Suzanne Beavers, Melissa Pagaoa, and Dolly J. Katz are with the Centers for Disease Control and Prevention, Atlanta, GA. Sally Hoger is with the Department of Medical Laboratory Sciences, Tarleton State University, Fort Worth, TX. Sharon Sharnprapai is with the Massachusetts Department of Public Health, Boston.
Objectives:
We compared mortality among tuberculosis (TB) survivors and a similar population.
Methods:
We used local health authority records from 3 US sites to identify 3853 persons who completed adequate treatment of TB and 7282 individuals diagnosed with latent TB infection 1993 to 2002. We then retrospectively observed mortality after 6 to 16 years of observation. We ascertained vital status as of December 31, 2008, using the Centers for Disease Control and Prevention's National Death Index. We analyzed mortality rates, hazards, and associations using Cox regression.
Results:
We traced 11 135 individuals over 119 772 person-years of observation. We found more all-cause deaths (20.7% vs 3.1%) among posttreatment TB patients than among the comparison group, an adjusted average excess of 7.6 deaths per 1000 person-years (8.8 vs 1.2; P < .001). Mortality among posttreatment TB patients varied with observable factors such as race, site of disease, HIV status, and birth country.
Conclusions:
Fully treated TB is still associated with substantial mortality risk. Cure as currently understood may be insufficient protection against TB-associated mortality in the years after treatment, and TB prevention may be a valuable opportunity to modify this risk.
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