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Interventions for reducing inflammation in familial Mediterranean fever
1Department of Pharmacy, West China Hospital, Sichuan University, No.37,Guoxue Lane, Chengdu, Sichuan, China, 610041.
The Cochrane Database of Systematic Reviews
|March 21, 2015
Summary
Limited studies show colchicine may reduce Familial Mediterranean Fever attacks, but more research is needed. Current evidence quality is low, necessitating further trials for other interventions.
Area of Science:
- Auto-inflammatory diseases
- Genetics and immunology
Background:
- Familial Mediterranean Fever (FMF) is a hereditary auto-inflammatory disease prevalent in Mediterranean populations.
- Colchicine has been historically used for FMF attack prevention.
- Alternative treatments like rilonacept, anakinra, and others are considered for colchicine-resistant or intolerant patients.
Purpose of the Study:
- To evaluate the efficacy and safety of interventions for reducing inflammation in patients with Familial Mediterranean Fever.
- To synthesize evidence from randomized controlled studies on FMF treatments.
Main Methods:
- Comprehensive literature search across multiple databases (CENTRAL, MEDLINE, Embase, etc.) and clinical trial registries.
- Inclusion of randomized controlled studies comparing active interventions (colchicine, rilonacept, ImmunoGuard™, etc.) against placebo or other active treatments.
- Independent study selection, data extraction, risk of bias assessment, and GRADE quality assessment.
Main Results:
- Four randomized controlled studies with 75 participants were included.
- One study indicated colchicine (0.6 mg TID) significantly reduced attacks (14% vs 100%), but with low GRADE evidence quality.
- Other studies showed no significant reduction for colchicine (0.5 mg BID) or rilonacept; ImmunoGuard™ did not reduce acute phase reactants.
Conclusions:
- Limited high-quality randomized controlled studies exist for FMF interventions.
- Colchicine shows potential in reducing FMF attacks, but evidence is based on few low-quality studies.
- Further rigorous randomized controlled trials are essential to establish the efficacy and safety of various FMF treatments.
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