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Effects of Metoclopramide on Feeding Intolerance among Preterm Neonates; A Randomized Controlled Trial

Mirhadi Mussavi1, Khairollah Asadollahi2, Ghobad Abangah3

  • 1Department of Pediatrics, Faculty of Medicine, Tabriz University of Medicine, Tabriz.

Iranian Journal of Pediatrics
|March 21, 2015
PubMed

Insights

Intravenous metoclopramide significantly reduced time to full enteral feeding and withheld feedings in preterm neonates with feeding intolerance. This study found no adverse effects, suggesting metoclopramide is a safe treatment option.

Area of Science:

  • Neonatal Medicine
  • Clinical Pharmacology
  • Pediatric Gastroenterology

Background:

  • Feeding intolerance is a common complication in preterm neonates.
  • Effective management strategies are crucial for improving outcomes in this vulnerable population.

Purpose of the Study:

  • To assess the efficacy and safety of intravenous metoclopramide for treating feeding intolerance in preterm neonates (less than 36 weeks gestational age).

Main Methods:

  • A randomized, controlled, masked cross-over study design.
  • Participants received either intravenous metoclopramide or placebo before feeding.
  • Key outcomes included time to full enteral feeding, adverse events, hospital stay, and incidence of necrotizing enterocolitis (NEC) or septicemia.

Main Results:

  • Metoclopramide group achieved full enteral feeding significantly faster (12.9±5.6 days) than the placebo group (17.0±6.3 days).
  • The number of withheld feedings was significantly lower in the metoclopramide group.
  • Regression analysis indicated metoclopramide use was associated with improved feeding parameters and no observed adverse effects.

Conclusions:

  • Intravenous metoclopramide may be a beneficial treatment for facilitating enteral feeding in preterm neonates with feeding intolerance.
  • The drug demonstrated a favorable safety profile in this study population.
Abstract

Keywords:
Feeding IntoleranceMeal FrequencyPrematuresVomiting

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