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Ocular Findings in Alemtuzumab (Campath-1H)-induced Thyroid Eye Disease

Tanya Trinh1, Anjana S Haridas, Timothy J Sullivan

  • 1†Department of Surgery, University of Queensland; and ‡Department of Ophthalmology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Ophthalmic Plastic and Reconstructive Surgery
|March 21, 2015
PubMed

Alemtuzumab (Campath-1H) is a humanized anti-CD52 monoclonal antibody used in the treatment of multiple sclerosis (MS). Studies demonstrate significant reduction in relapse risk and the risk of accumulating sustained disability. Adverse events include infusion-associated reactions, infections, and secondary autoimmunity. Systemic thyroid disease is the most common secondary autoimmune event and affects up to approximately 30% of treated patients. This is the first description of the ocular findings and management in a case of thyroid eye disease (Graves' Ophthalmopathy [GO]) following alemtuzumab therapy. The ocular disease was managed conservatively while the systemic Graves' was managed with thyroidectomy.

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