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Updated: Apr 16, 2026
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
[Role of the Sonic Hedgehog pathway in thoracic cancers]
E Giroux Leprieur1, M Antoine2, T Vieira3
1Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; EA4340 BCOH, service de pneumologie et oncologie thoracique, hôpital Ambroise-Paré, AP-HP, université Versailles-Saint-Quentin-en-Yvelines, 92100 Boulogne-Billancourt, France.
Introduction:
Sonic Hedgehog (Shh) pathway is physiologically activated during embryogenesis and development. It plays a role in idiopathic lung fibrosis and is also activated in several solid cancers.
State Of The Art:
Shh pathway is reactivated in thoracic cancers, as small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma. Shh pathway is associated with cancer stem cells and seems to have a crucial role in tumor proliferation, aggressiveness and chemoresistance in these cancers. This review describes the activation mode of Shh pathway in thoracic cancers and its role in small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma, using in vitro and in vivo models. Notably, data from literature show that inhibition of Shh pathway has an antitumor action and sensitizes to chemotherapy.
Perspectives:
These results incite to develop targeted therapies against Shh pathway in the treatment of thoracic cancers.
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