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Regular aspirin use and stomach cancer risk in China
1Department of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, China.
Objective:
Epidemiological studies on aspirin and stomach cancer have been inconclusive. The purpose of our study was to investigate the association between aspirin and stomach cancer in China.
Method:
A 1:2 matched case-control study was conducted in four large medical centers. A self-designed questionnaire was used to collect information. Unconditional logistic regression was used to compute crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).
Result:
Our study indicated that risk of stomach cancer was greatly reduced for regular aspirin user (OR = 0.62; 95% CI 0.42-0.80). Specifically, dosage and tablet-years of use were associated with lower risk (OR = 0.54; 95% CI 0.29-0.84 for ≥7 tabs/week; OR = 0.47; 95% CI 0.32-0.81 for ≥10 tablet years, respectively). Furthermore, the finding was strengthened by stratified studies of gender, smoking status, body mass index (BMI) and helicobacter pylori.
Conclusion:
Our study confirmed that regular aspirin use is a protective factor to stomach cancer.
