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Poststreptococcal glomerulonephritis in a patient with essential thrombocytosis

Sukru Ulusoy¹, Gulsum Ozkan, Mehmet Sonmez

¹Department of Nephrology, School of Medicine, Karadeniz Technical University.

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi

|March 24, 2015

Abstract:

In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. These characteristics make our case the first to be reported in the literature.

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