Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

4.6K
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting RNA structures.

Nature methods·2025
Same author

From blobology to atomic resolution.

Nature methods·2024
Same author

A dynamic direction for cryo-EM.

Nature methods·2022
Same author

Tracking protein conformation in live cells.

Nature methods·2021
Same author

Graphene-on-gold grids for cryo-EM.

Nature methods·2019
Same author

Probes for protein prenylation.

Nature methods·2019
Same journal

ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.

Nature methods·2026
Same journal

RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

Nature methods·2026
Same journal

Spatio-DARLIN enables robust and efficient in situ lineage tracing in mice at single-cell resolution.

Nature methods·2026
Same journal

EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control.

Nature methods·2026
Same journal

Cloud-based microscope enables live neuroimaging for 24 h and beyond with worldwide access.

Nature methods·2026
Same journal

Deep molecular profiling in three dimensions.

Nature methods·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy
09:16

Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy

Published on: February 7, 2022

7.6K

Cryo-EM strikes gold

Allison Doerr

    Nature Methods
    |March 24, 2015
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Single Particle Cryo-Electron Microscopy: From Sample to Structure
    11:52

    Single Particle Cryo-Electron Microscopy: From Sample to Structure

    Published on: May 29, 2021

    10.0K
    Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
    13:43

    Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

    Published on: June 24, 2013

    14.7K

    Related Experiment Videos

    Last Updated: Apr 15, 2026

    Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy
    09:16

    Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy

    Published on: February 7, 2022

    7.6K
    Single Particle Cryo-Electron Microscopy: From Sample to Structure
    11:52

    Single Particle Cryo-Electron Microscopy: From Sample to Structure

    Published on: May 29, 2021

    10.0K
    Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
    13:43

    Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

    Published on: June 24, 2013

    14.7K