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[Search for new modes of antibiotic prophylaxis of septic complications after percutaneous nephrolithotripsy]

T S Perepanova, S K Zyrianov, A V Sokolov

    Urologiia (Moscow, Russia : 1999)
    |March 25, 2015
    PubMed

    Insights

    Infectious complications after percutaneous nephrolithotomy (PNL) are linked to biofilms within kidney stones. This study compares ciprofloxacin administration methods to prevent such risks.

    Area of Science:

    • Urology
    • Infectious Diseases
    • Pharmacokinetics

    Context:

    • Percutaneous nephrolithotomy (PNL) carries a risk of infectious and inflammatory complications.
    • Biofilms within kidney stones harbor microorganisms, posing a threat during stone destruction.
    • Bacteria and toxins can migrate into the bloodstream during PNL, leading to sepsis.

    Purpose:

    • To investigate the pharmacokinetic parameters of ciprofloxacin.
    • To compare the effectiveness of two ciprofloxacin administration modes (bolus vs. prolonged intravenous) at 1000 mg for antimicrobial prophylaxis after PNL.

    Summary:

    • Destruction of kidney stones during PNL can dislodge bacteria from biofilms, potentially causing septic complications.
    • Ciprofloxacin's pharmacokinetic profile was studied under different intravenous administration regimens.
    • Prolonged intravenous administration may offer advantages in achieving therapeutic concentrations for prophylaxis.

    Impact:

    • Provides evidence for optimizing antibiotic prophylaxis strategies in PNL.
    • Aims to reduce the incidence of infectious complications following percutaneous kidney stone interventions.
    • Informs clinical decisions regarding antibiotic selection and administration for preventing post-PNL sepsis.

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