Related Experiment Video
Updated: Apr 15, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Injectable Coformulations in Diabetology.
1Bharti Hospital and B.R.I.D.E, Karnal, Haryana, 132001, India, brideknl@gmail.com.
Novel coformulations combine two diabetes medications, like insulin and GLP1 receptor agonists, into single injections. These fixed-dose combinations offer distinct pharmacokinetic and pharmacodynamic profiles for improved diabetes management.
Area of Science:
- Pharmaceutical development
- Diabetology
- Pharmacology
Background:
- Coformulations represent a novel advancement in diabetes treatment.
- These products combine two distinct medicinal agents.
- Existing coformulations include insulin and glucagon-like peptide 1 receptor agonist (GLP1RA) combinations.
Purpose of the Study:
- To review emerging coformulations in diabetology.
- To discuss the pharmacology and clinical usage of these novel drug delivery systems.
- To highlight three coformulations in advanced development or market approval.
Main Methods:
- Literature review of coformulation development and clinical data.
- Analysis of basic and clinical pharmacology.
- Description of clinical usage for approved products like insulin degludec aspart (IDegAsp).
Main Results:
- Coformulations maintain individual drug properties.
- Several coformulations are in late-stage development or approved.
- Insulin degludec aspart (IDegAsp) is a commercially available example.
Conclusions:
- Coformulations offer a promising new therapeutic avenue in diabetes care.
- Understanding their pharmacology is crucial for effective clinical application.
- These fixed-combination products have the potential to simplify treatment regimens.
More Related Videos
09:31Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
09:39Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Related Concept Videos
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Oral Hypoglycemic Agents: Glinides
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Oral Hypoglycemic Agents: Sulfonylureas