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The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major

David Preiss1, Ross T Campbell2, Heather M Murray3

  • 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK david.preiss@glasgow.ac.uk.

European Heart Journal
|March 25, 2015
PubMed

Insights

Statins modestly lower the risk of heart failure (HF) hospitalization and composite HF events. However, the study found no significant reduction in heart failure death with statin use.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • The impact of statin therapy on heart failure (HF) hospitalization and mortality remains incompletely understood.
  • Statins are widely used for cardiovascular disease prevention, necessitating clarity on their effects on HF outcomes.

Purpose of the Study:

  • To investigate the efficacy of statins in reducing major adverse heart failure events.
  • To determine if statins decrease the risk of HF hospitalization and HF-related death.

Main Methods:

  • A meta-analysis of randomized controlled statin trials (1994-2014) was conducted, including primary and secondary prevention studies with over 1000 participants and >1 year follow-up.
  • Data from adverse event reports were obtained from collaborating trialists.
  • Outcomes included non-fatal HF hospitalization, HF death, and a composite endpoint. Fixed-effects meta-analyses were used to calculate risk ratios (RR).

Main Results:

  • The meta-analysis included up to 17 trials with 132,538 participants.
  • Statin therapy significantly reduced non-fatal HF hospitalizations (RR 0.90, 95% CI 0.84-0.97) and the composite HF outcome (RR 0.92, 95% CI 0.85-0.99).
  • No significant reduction was observed for HF death (RR 0.97, 95% CI 0.80-1.17).

Conclusions:

  • Statins offer a modest benefit in reducing the risk of non-fatal heart failure hospitalization.
  • A composite outcome of non-fatal HF hospitalization or HF death was also reduced by statins.
  • The risk reduction for HF hospitalization was consistent regardless of whether a myocardial infarction (MI) preceded the event.
Abstract

Keywords:
Heart failureMeta-analysisPreventionRandomized trialStatin

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