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Cutaneous epithelioid osteoblastoma.

Jeffrey S Mohlman1, Katherine A Diaz, John D Schaber

  • 1*Office of Student Affairs, El Paso, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX; and †Department of Pathology, William Beaumont AMC, El Paso, TX.

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Epithelioid osteoblastomas (EOB) are rare bone tumors that can occur in soft tissue, including tattooed skin. This case highlights osteoblastic differentiation in a military veteran, suggesting a potential link to military service.

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Area of Science:

  • Oncology
  • Dermatopathology
  • Orthopedic Pathology

Background:

  • Epithelioid osteoblastomas (EOB) are typically found in the axial skeleton.
  • Soft tissue EOB are exceptionally rare, with limited literature and debate regarding their neoplastic nature.

Observation:

  • A case of EOB with confirmed osteoblastic differentiation is presented.
  • The tumor arose in the tattooed skin of a 32-year-old male military veteran.
  • The osteoblastic marker SAT2B confirmed the tumor's differentiation.

Findings:

  • This report details a unique case of epithelioid osteoblastoma in tattooed skin.
  • Two other soft tissue EOB cases involved military personnel, suggesting a potential pattern.
  • The demographic prevalence in young males, common in the military, may explain this observation.

Implications:

  • This case expands the known sites for EOB, including cutaneous locations.
  • The findings may prompt further investigation into potential occupational risk factors for soft tissue EOB in military service.
  • The use of SAT2B is validated as a marker for osteoblastic differentiation in EOB.