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Glucocorticoid signaling in the heart: A cardiomyocyte perspective

Robert H Oakley1, John A Cidlowski1

  • 1Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, P.O. Box 12233, MD F3-07, Research Triangle Park, North Carolina 27709, USA.

The Journal of Steroid Biochemistry and Molecular Biology
|March 26, 2015
PubMed

Insights

Glucocorticoid receptor (GR) signaling in heart cells is vital for normal heart development and function. Mineralocorticoid receptor (MR) signaling in these cells contributes to cardiac disease progression.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Heart failure is a major cause of death globally.
  • Glucocorticoids are critical stress hormones with known cardiovascular effects.
  • The direct role of glucocorticoid signaling in the heart remains incompletely understood.

Purpose of the Study:

  • To review the role of glucocorticoid signaling in cardiomyocytes.
  • To discuss insights from genetic mouse models targeting GR and MR in the heart.
  • To elucidate the impact of cardiomyocyte glucocorticoid signaling on heart physiology and pathophysiology.

Main Methods:

  • Utilizing transgenic mouse models to specifically target glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in cardiomyocytes.
  • Investigating the in vivo function of GR and MR signaling pathways within the heart.
  • Analyzing the physiological and pathophysiological consequences of altered glucocorticoid signaling in the heart.

Main Results:

  • GR signaling in cardiomyocytes is essential for normal cardiac development and function.
  • MR signaling in cardiomyocytes plays a role in the development and progression of cardiac disease.
  • Genetic models provide new understanding of direct cardiomyocyte glucocorticoid signaling.

Conclusions:

  • Cardiomyocyte glucocorticoid signaling, mediated by GR and MR, significantly influences heart health.
  • GR signaling is protective, while MR signaling is detrimental in the context of cardiac disease.
  • Further research into these pathways can inform therapeutic strategies for heart failure.
Keywords:
CardiomyocytesGlucocorticoid receptorGlucocorticoidsMineralocorticoid receptorTransgenic mice

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