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Updated: Apr 15, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Bidirectional interactions of NK cells and dendritic cells in immunotherapy: current and future perspective
Sajid Mahmood1, Deepak Upreti, Ibrahim Sow
1Department of Immunology, Room 417 Apotex Center, 750 McDermot Avenue, Winnipeg, Manitoba R3E 0T5, Canada.
Abstract:
NK cells and dendritic cells (DC) are innate cellular components that regulate adaptive immune responses in the immune surveillance of cancer and infections. Interactions of NK and DC are bidirectional. In this mini review, we summarized how NK cells regulate immature DC editing and maturation, how DC regulate NK-cell functions reciprocally in the NK-DC crosstalk, and the importance of NK-DC crosstalk in antitumor immunity. Enhancing NK-DC crosstalk by cellular factor(s), antibodies or creating a microenvironment that promote NK activations, DC maturation and NK-DC crosstalk will provide new insights into future development of DC-based immunotherapy.
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