3D-printed system optimizing dissolution of hyperpolarized gaseous species for micro-sized NMR

Area of Science:

• Nuclear Magnetic Resonance (NMR) Spectroscopy
• Hyperpolarized Contrast Agents
• Fluid Dynamics in Magnetic Fields

Background:

• Bubble formation in liquids obstructs Nuclear Magnetic Resonance (NMR) experiments by reducing field homogeneity.
• Efficient dissolution of hyperpolarized agents is crucial for high-resolution NMR imaging and spectroscopy.
• Existing methods for bubble removal can be cumbersome and less effective in confined spaces.

Purpose of the Study:

• To develop and evaluate a novel 3D-printed device for bubble removal in hyperpolarized liquid dissolution.
• To enhance field homogeneity and improve the dissolution of hyperpolarized gases within NMR systems.
• To demonstrate the efficacy of the device using hyperpolarized xenon in water.

Main Methods:

• Fabrication of a combined bubble pump and miniaturized NMR cell using 3D printing technology.
• Integration of the device within the narrow bore of an NMR magnet.
• Conducting (129)Xe Nuclear Magnetic Resonance (NMR) experiments with hyperpolarized xenon gas in water.

Main Results:

• The 3D-printed device successfully removed bubbles, leading to improved field homogeneity.
• High and homogeneous dissolution of hyperpolarized xenon in water was achieved.
• The integrated system demonstrated efficient gas-liquid dissolution for NMR applications.

Conclusions:

• The developed 3D-printed device offers a practical solution for bubble-related challenges in hyperpolarized NMR.
• This innovation facilitates more reliable and higher-quality NMR experiments involving dissolved hyperpolarized gases.
• The technology holds promise for advancing applications in medical imaging and chemical analysis requiring hyperpolarized agents.