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Updated: Apr 15, 2026

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
Published on: June 9, 2017
An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and
Hongmei Zhang1, Chenglong Xu, Jie Liu
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 China. xinmingli@suda.edu.cn.
Abstract:
We report the design and synthesis of a novel probe (1) for ALP assay by incorporating a self-immolative linker between a phosphate moiety and resorufin. Because of its good biocompatibility and rapid cell internalization, this probe also exhibited great potential for real-time monitoring of endogenous phosphatase activity in living cells.
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