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Updated: Apr 15, 2026
09:13
Quantitative Immunofluorescence to Measure Global Localized Translation
Published on: August 22, 2017
10.6K
How old is "too old" for translational research?
Alain Vergnenegre1, Romain Corre1, Hervé Lena1
11 Service de Pathologie Respiratoire, CHU-Limoges, France ; 2 Groupe Français de Pneumo-Cancerologie (GFPC), France ; 3 Service de Pneumologie CHU-Rennes, France ; 4 Service de Pneumologie CH-Draguignan, France.
Translational Lung Cancer Research
|March 26, 2015
Summary
Targeted therapies are effective for elderly lung cancer patients, even with age-related biological changes. These advanced treatments, including tyrosine kinase inhibitors, offer optimal choices for older individuals with non-small cell lung cancer.
Area of Science:
- Oncology
- Geriatric Medicine
- Pharmacology
Background:
- Biomarker assessments are crucial for lung cancer management.
- Aging influences cancer biology, including mitochondrial dysfunction and nutrient sensing.
- Elderly patients undergo similar diagnostic assessments as younger patients.
Purpose of the Study:
- To review the application of targeted therapies in elderly lung cancer patients.
- To discuss the efficacy and considerations of targeted treatments in older adults.
Main Methods:
- Systematic literature review using keywords: "elderly", "lung cancer", "targeted therapy".
- Analysis of published papers focusing on biological modifications in the elderly and their impact on cancer treatment.
Main Results:
- Targeted therapies, including tyrosine kinase inhibitors (TKIs) and antiangiogenic agents, are utilized in non-small cell lung cancer (NSCLC).
- These therapies are discussed in both selected and unselected elderly patient populations.
- Biological changes associated with aging are described in relation to cancer biology.
Conclusions:
- Targeted therapies are a viable and often optimal treatment option for elderly patients with lung cancer.
- Age-related biological changes do not preclude the effective use of targeted therapies in this demographic.
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