Related Experiment Video

Updated: Apr 15, 2026

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

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Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line

Joseph B Moore1, David M Loeb2, Kyung U Hong3

  • 1Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Baltimore, MD, USA ; Department of Medicine, Institute of Molecular Cardiology, University of Louisville Louisville, KY, USA.

Frontiers in Cell and Developmental Biology
|March 26, 2015
PubMed
Summary

Induced pluripotent stem (iPS) cells were generated from Ewing sarcoma (EWS) cells, creating a model for studying cancer drug resistance. These EWS-iPS cells retained drug resistance but regained sensitivity upon differentiation, offering insights into oncogenesis and metastasis.

Keywords:
Ewing sarcomadrug resistanceepigeneticsinduced pluripotent stem cellsreprogramming

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