[Nucleotide receptors and the cell motility]

The ability to active motility is one of the fundamental features of both normal and pathologically transformed cells. The current paper de- scribes the role of nucleotide receptors in regulation of cell motility in higher organisms. Author focuses on those cells which actively move in the nucleotide gradients: immune system cells as well as glia cells. The impact of individual receptors in motility and current opinions on the role of signaling pathways activated by those receptors will be described. The source of nucleotides regulating motility will be proposed and role of extracellular nucleotides such as ATP, ADP, UTP and adenosine will be indicated. The role of ectoenzymes in creation of secondary nucleotide gradients regulating cell motility will also be indicated. Finally, the role of nucleotides in regulation of brain tumor cells will be described and perspective of possible therapeutic role of modulation nucleotide signaling influencing cell motility will be suggested.