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Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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Ultra-sensitive nanofiber fluorescence detection in a microfluidic chip.

Zhiyong Li1, Yingxin Xu2, Wei Fang3

  • 1State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou 310027, China. lizhiyong@zju.edu.cn.

Sensors (Basel, Switzerland)
|March 27, 2015
PubMed
Summary

We developed a highly sensitive fluorescence sensor using a biconical taper for detecting rhodamine 6G and quantum dots. This robust sensor offers excellent reversibility and low detection limits for chemical and biosensing applications.

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Area of Science:

  • Optical sensing
  • Nanotechnology
  • Biochemistry

Background:

  • Fluorescence sensors are crucial for detecting analytes.
  • Existing sensors often face challenges with sensitivity and stability.
  • Microfluidic integration can enhance sensor performance.

Purpose of the Study:

  • To develop an ultra-sensitive and robust fluorescence sensor.
  • To embed a biconical taper within a microchannel for enhanced stability.
  • To assess the sensor's performance for chemical and biological analytes.

Main Methods:

  • Fabrication of a biconical taper with a 720 nm waist diameter.
  • Embedding the taper within a 125 µm microchannel.
  • Measuring fluorescence intensity of rhodamine 6G and quantum dot-labeled streptavidin.

Main Results:

  • Achieved a detection limit of 100 pM for rhodamine 6G with excellent reversibility (0-10 nM).
  • Demonstrated a detection sensitivity down to 10 pM for quantum dots.
  • The sensor utilizes a small sample volume (500 nL) and offers high throughput.

Conclusions:

  • The biconical taper fluorescence sensor provides ultra-high sensitivity and robustness.
  • Microchannel integration significantly enhances sensor stability.
  • The developed sensor is advantageous for various chemical and biosensing applications.