Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection.

Mucosal immunology·2016

Same author

Ia antigens on non-lymphoid tissues their origins and functions.

Immunology today·2014

Same author

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine.

Mucosal immunology·2014

Same author

HIV-1 drug resistance prevalence, drug susceptibility and variant characterization in the Jacobi Medical Center paediatric cohort, Bronx, NY, USA.

HIV medicine·2013

Same author

Peripheral CD8+ T-cell levels are decreased in atopic wheezing children aged less than 4 years.

Journal of investigational allergology & clinical immunology·2012

Same author

NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.

Scandinavian journal of immunology·2011

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Antiviral gene expression in psoriasis.

R A Raposo^1,2, R Gupta³, M Abdel-Mohsen^4,5

¹Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.

Journal of the European Academy of Dermatology and Venereology : JEADV

|March 27, 2015

Summary

Psoriasis involves increased antiviral gene expression in the skin, but not blood, indicating localized immune activation against viruses. This suggests psoriasis is a skin-specific inflammatory condition with antiviral defenses.

More Related Videos

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

Published on: May 15, 2014

Quantitative Fluorescence In Situ Hybridization FISH and Immunofluorescence IF of Specific Gene Products in KSHV-Infected Cells

Quantitative Fluorescence In Situ Hybridization FISH and Immunofluorescence IF of Specific Gene Products in KSHV-Infected Cells

Published on: August 27, 2019

Related Experiment Videos

Last Updated: Apr 15, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

Published on: May 15, 2014

Quantitative Fluorescence In Situ Hybridization FISH and Immunofluorescence IF of Specific Gene Products in KSHV-Infected Cells

Quantitative Fluorescence In Situ Hybridization FISH and Immunofluorescence IF of Specific Gene Products in KSHV-Infected Cells

Published on: August 27, 2019

Area of Science:

Immunology
Dermatology
Virology

Background:

Psoriasis patients exhibit fewer viral infections than atopic dermatitis patients.
Elevated expression of antiviral proteins (e.g., MX1, ISG15) is noted in psoriatic skin.
Genetic studies link psoriasis susceptibility to antiviral pathways.

Purpose of the Study:

To investigate pervasive antiviral gene expression in the skin and blood of psoriasis patients.
To compare antiviral gene expression in psoriasis, atopic dermatitis, and healthy controls.

Main Methods:

RNA sequencing of skin samples from psoriasis patients and healthy controls.
Analysis of 42 predefined antiviral genes.
HIV-1 infectivity assays in T cells.

Main Results:

Significant overexpression of 16 antiviral genes in lesional psoriatic skin (e.g., ISG15, RSAD2).
No overexpression of these antiviral genes in atopic dermatitis or non-lesional psoriatic skin.
No differences in antiviral gene expression in peripheral blood; similar HIV-1 infectivity in T cells.

Conclusions:

Psoriasis demonstrates localized immune activation in the skin against viral pathogens.
The immune response in psoriasis is cutaneous, not systemic.
Findings underscore psoriasis as an inflammatory disease with specific skin-based antiviral activity.