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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis III01:31

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Apr 15, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Cellular therapy in tuberculosis.

Shreemanta K Parida1, Rajhmun Madansein2, Nalini Singh3

  • 1Therapeutic Immunology Division, Dept of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|March 27, 2015
PubMed
Summary
This summary is machine-generated.

Mesenchymal stromal cells (MSCs) show promise as an adjunct therapy for drug-resistant tuberculosis (TB). MSCs may limit tissue damage and improve immune responses against Mycobacterium tuberculosis.

Keywords:
HDTM.tuberculosisMDR-TBMesenchymal stromal cellsT-cellsTuberculosiscancerhost directed therapyinflammation

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Infectious Diseases

Background:

  • Drug-resistant tuberculosis (TB) presents a significant therapeutic challenge.
  • Current treatments for multi-drug resistant TB (MDR-TB) have limitations.
  • Cellular therapies offer potential new avenues for TB treatment.

Purpose of the Study:

  • To review the role of Mesenchymal stromal cells (MSCs) in infectious diseases, focusing on their application in drug-resistant TB.
  • To discuss the immunomodulatory and regenerative properties of MSCs relevant to TB therapy.
  • To explore the potential of MSCs as adjunct therapy for MDR-TB.

Main Methods:

  • Review of existing literature on MSCs and their function in infectious diseases.
  • Analysis of MSC mechanisms, including immune modulation and tissue repair.
  • Discussion of the potential clinical applications of MSCs in MDR-TB treatment.

Main Results:

  • MSCs are tissue-resident progenitor cells with immune-modulatory and anti-inflammatory properties.
  • MSCs can home to injured tissues, promote stem cell proliferation, and restore lung epithelium.
  • MSC-mediated effects are achieved through cell-cell contacts and soluble factors.

Conclusions:

  • MSCs hold promise as an adjunct cellular therapy for drug-resistant TB.
  • MSC therapy may limit tissue damage and convert unproductive inflammation into effective anti-pathogen responses.
  • Adjunct cellular therapy with MSCs could offer salvage options, enhance anti-TB immune responses, and potentially shorten treatment duration.