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Updated: Apr 15, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Tuberculosis and chronic respiratory disease: a systematic review
Anthony L Byrne1, Ben J Marais2, Carole D Mitnick3
1The University of Sydney, Australia; Socios En Salud Sucursal, Partners In Health, Lima, Perú; Centre for Research Excellence in Tuberculosis (TB-CRE), Sydney, Australia.
A history of tuberculosis is strongly linked to chronic respiratory diseases like COPD, especially in high-incidence areas. Integrated lung health strategies within tuberculosis care are crucial for long-term patient well-being.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Epidemiology
Background:
- Chronic respiratory diseases represent a significant global health burden.
- The role of pulmonary tuberculosis in the development of chronic respiratory disease is often underestimated, particularly in endemic regions.
Purpose of the Study:
- To systematically review and assess the association between a history of tuberculosis and the presence of chronic obstructive pulmonary disease (COPD) or bronchiectasis.
- To evaluate the impact of tuberculosis on long-term lung health.
Main Methods:
- Systematic literature review of eligible studies.
- Quality assessment of studies using the National Heart Lung and Blood Institute tool.
- Meta-analysis conducted using the DerSimonian and Laird random effects model.
Main Results:
- Nine studies reported an association between tuberculosis history and COPD, and two studies examined bronchiectasis.
- A significant association was found between tuberculosis history and COPD in adults over 40 (pooled OR 3.05).
- Stronger associations were observed in high tuberculosis incidence countries, among never-smokers, and younger individuals.
Conclusions:
- Tuberculosis is a significant risk factor for chronic respiratory disease in adults living in tuberculosis-endemic areas.
- Tuberculosis care should incorporate strategies to improve long-term lung health outcomes.
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