Related Experiment Video

Updated: Apr 15, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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The emerging role of miRNAs in combined cancer therapy

Hong W Yu1, William C Cho

  • 1Hong Kong Polytechnic University, Department of Health Technology and Informatics , Kowloon, Hong Kong , China.

Expert Opinion on Biological Therapy
|March 28, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate cell processes and can act as oncomiRs or tumor suppressors in cancer. Harnessing miRNA therapy, especially with antagomiRs, shows promise for novel cancer treatments, potentially combined with existing therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing cellular development, differentiation, and fundamental biological processes.
  • miRNAs play a dual role in cancer, acting as oncogenes (oncomiRs) or tumor suppressors, impacting cell transformation and proliferation.
  • Specific silencing of miRNAs can be achieved using antisense miRNAs (antagomiRs) introduced into cells via methods like lipofection or electroporation.
Keywords:
chemotherapycombined cancer therapyimmunotherapymicroRNAradiotherapy

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