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Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the
Luca Guandalini1, Maria Vittoria Martino1, Lorenzo Di Cesare Mannelli2
1Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
Abstract:
A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure-activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.