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Updated: Apr 15, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

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[Present and future in the management of venous vascular diseases]

Peter Gavorník, Andrej Dukát, Ľudovít Gašpar

    Vnitrni Lekarstvi
    |March 28, 2015
    PubMed

    Insights

    Chronic venous vascular diseases are globally prevalent, with severe cases underestimated. Micronized purified flavonoid fraction (MPFF) is recommended for leg ulcers, alongside other treatments for venous conditions and thrombosis prevention.

    Area of Science:

    • Vascular Medicine
    • Phlebology
    • Epidemiology

    Background:

    • Chronic and acute venous vascular diseases exhibit high global prevalence.
    • Advanced venous failure cases are more common than previously estimated.
    • Venous diseases significantly impact public health worldwide.

    Purpose of the Study:

    • To review current understanding and management of chronic and acute venous vascular diseases.
    • To highlight effective therapeutic options for venous insufficiency and thrombosis.
    • To emphasize the significance of venous diseases as a global health concern.

    Main Methods:

    • Review of epidemiological data on venous vascular disease prevalence and incidence.
    • Analysis of current pharmacotherapeutic options, including venoactive drugs (VADs) and anticoagulants.
    • Evaluation of invasive treatment modalities like compressive sclerotherapy.

    Main Results:

    • Micronized purified flavonoid fraction (MPFF) is a highly recommended VAD for leg ulcer healing.
    • Compressive sclerotherapy is effective for treating superficial venous abnormalities.
    • Direct oral anticoagulants (DOACs) are key for deep venous thrombosis (DVT) and venous thromboembolism (VTE) prevention, with specific limitations.

    Conclusions:

    • Venous vascular diseases represent a significant global health challenge.
    • A combination of pharmacotherapy and interventional procedures offers effective management strategies.
    • Prophylaxis against venous thromboembolism is crucial, especially in high-risk populations.

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