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Related Experiment Video

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Brain functional network changes following Prelimbic area inactivation in a spatial memory extinction task.

Marta Méndez-Couz1, Nélida M Conejo1, Guillermo Vallejo2

  • 1Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, Plaza Feijoo, s/n E-33003, Oviedo, Spain.

Behavioural Brain Research
|March 28, 2015
PubMed
Summary

Inactivating the prelimbic cortex did not impair spatial memory extinction in rats. However, it altered functional brain networks, highlighting the mammillary bodies

Keywords:
Brain networksCytochrome oxidaseExtinctionMuscimolPrefrontal cortexSpatial memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Background:

  • The prefrontal cortex, particularly the prelimbic and infralimbic areas, is implicated in spatial memory processes.
  • Recent findings suggest these areas are involved in the late stages of spatial memory extinction.

Purpose of the Study:

  • To investigate if inactivating the prelimbic area of the prefrontal cortex affects spatial memory extinction.
  • To explore the functional brain networks associated with spatial memory extinction under prelimbic cortex inactivation.

Main Methods:

  • Male Wistar rats were trained in a hidden platform water maze task.
  • The prelimbic cortex was inactivated using Muscimol, a GABAA receptor agonist, before extinction training.
  • Cytochrome c oxidase histochemistry was used to map metabolic brain activity and analyze interregional correlations.

Main Results:

  • Rats successfully acquired reference memory and completed the extinction task without significant impairment after prelimbic cortex inactivation.
  • Analysis of cytochrome c oxidase activity revealed altered functional brain network correlations in the Muscimol-treated group compared to the saline-treated group.
  • These network changes suggest the involvement of the mammillary bodies in the late stages of memory extinction.

Conclusions:

  • Inactivation of the prelimbic cortex does not abolish spatial memory extinction.
  • Functional brain network dynamics, including the mammillary bodies, are modulated during spatial memory extinction.