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Celsr3 and Fzd3 in axon guidance
Guoliang Chai1, Andre M Goffinet1, Fadel Tissir1
1Institute of Neuroscience, Université catholique de Louvain, 73 Avenue Mounier, B1.73.16, Brussels 1200, Belgium.
The International Journal of Biochemistry & Cell Biology
|March 28, 2015
Summary
Axon guidance relies on extracellular cues. Novel research explores Celsr3 and Fzd3 receptors in neuronal wiring, highlighting their role in central and peripheral nervous system development, though molecular mechanisms require further study.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Functional neuronal circuits require precise axon and dendrite wiring.
- Axon guidance is mediated by extracellular cues like Netrins, Ephrins, Semaphorins, and Slits, acting through growth cone receptors.
- Planar cell polarity proteins, including Celsr3 and Fzd3, are newly recognized key players in axon guidance.
Purpose of the Study:
- To review recent advances in understanding the role of Celsr3 and Fzd3 in axon guidance.
- To discuss the current knowledge gaps and future research directions in this emerging field.
Main Methods:
- Literature review of recent studies on Celsr3 and Fzd3 in axon guidance.
- Analysis of the known functions of these receptors in central and peripheral nervous system development.
Main Results:
- Celsr3 and Fzd3 are crucial for the development of most longitudinal tracts in the central nervous system.
- These receptors also regulate axon navigation in the peripheral, sympathetic, and enteric nervous systems.
- The specific extracellular ligands, co-receptors, and downstream effectors for Celsr3 and Fzd3 remain largely unknown.
Conclusions:
- Celsr3 and Fzd3 play a significant role in establishing complex neuronal connectivity.
- Further research is needed to elucidate the molecular mechanisms underlying Celsr3 and Fzd3 function in axon guidance.
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