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Updated: Apr 15, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Efficacy of tobramycin aerosol in nasal polyposis
P Bonfils1, V Escabasse2, A Coste2
1Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris-Descartes, Université Paris V, 20, Rue Leblanc, 75015 Paris, France.
Context:
Treatment of infected nasal polyposis.
Material And Methods:
Multicenter interventional prospective double-blind randomized study with matched groups: treatment with tobramycin aerosol versus isotonic saline aerosol. The study population included 55 patients: 23 receiving isotonic saline aerosol and 32 receiving tobramycin. A novel device (Easynose®) was used with an original principle limiting pulmonary deposition and ensuring homogeneous peripheral deposition in the nasal cavities.
Objectives:
The principal objective was to compare bacteriological eradication between tobramycin 150mg/3ml versus isotonic saline, both administered by nebulization via the Easynose® device.
Results And Conclusion:
Tobramycin aerosol administered via the Easynose® device showed significantly better bacteriological eradication than isotonic saline.
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