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Genetic amniocentesis: a twelve years' experience
American Journal of Medical Genetics
|March 1, 1985
Summary
Genetic amniocentesis is a safe and accurate prenatal diagnostic procedure. It effectively identifies fetal abnormalities, with a low error rate, aiding in the detection of genetic defects.
Area of Science:
- Medical Genetics
- Prenatal Diagnosis
- Obstetrics
Background:
- Genetic amniocentesis is a key prenatal diagnostic tool.
- Evaluating its safety, accuracy, and incidence of abnormal findings is crucial.
Purpose of the Study:
- To analyze the incidence of abnormal findings in fetuses.
- To assess the safety and accuracy of genetic amniocentesis.
- To evaluate the impact of concurrent ultrasonography.
Main Methods:
- Analysis of 2,013 fetuses from 2,000 patients undergoing genetic amniocentesis.
- Review of pregnancy outcomes, including spontaneous abortion and termination.
- Calculation of error rates and tissue culture success rates.
- Comparison of outcomes with and without concurrent ultrasonography.
Main Results:
- 1% of fetuses were aneuploid, 1% had elevated alpha-fetoprotein.
- Advanced maternal age was a primary indication for amniocentesis.
- The procedure had a 0.15% error rate and 97.7% tissue culture success.
- Concurrent ultrasonography reduced blood-tinged specimens from 15.0% to 5.2%.
Conclusions:
- Midtrimester amniocentesis is a safe and accurate procedure for prenatal diagnosis.
- It is valuable for identifying fetal abnormalities and genetically determined defects.
- Ultrasonography enhances specimen quality during the procedure.