Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

29.0K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
29.0K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

28.5K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
28.5K
Production of Formed Elements01:34

Production of Formed Elements

7.2K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
7.2K
Plastic Deformation in Circular Shafts01:20

Plastic Deformation in Circular Shafts

578
When materials are subjected to forces that surpass their yield strength, they undergo a process known as plastic deformation. This results in a permanent alteration or strain in their structure. This concept can be specifically applied to circular shafts, where the deformation leads to a change in its shape. The precise evaluation of this plastic deformation requires understanding the stress distribution within the circular shaft, which is achieved by calculating the maximum shearing stress in...
578
The DNA Helix01:07

The DNA Helix

31.9K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
31.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.

Molecular cell·2025
Same author

Programmable DNA shell scaffolds for directional membrane budding.

Nature communications·2025
Same author

Bio Meets Nano: Protein Exchange in Saline Biocoronae on Magnetic Nanoparticles.

International journal of molecular sciences·2025
Same author

Photothermally Powered 3D Microgels Mechanically Regulate Mesenchymal Stem Cells Under Anisotropic Force.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Biocorona on Iron Oxide Nanoparticles in a Complex Biotechnological Environment: Analysis of Proteins, Lipids, and Carbohydrates.

Small science·2025
Same author

Efficient DNA- and virus-free engineering of cellular transcriptomic states using dCas9 ribonucleoprotein (dRNP) complexes.

Nucleic acids research·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.3K

Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components.

Thomas Gerling1, Klaus F Wagenbauer1, Andrea M Neuner1

  • 1Physik Department, Walter Schottky Institute, Technische Universität München Am Coulombwall 4a, 85748 Garching near Munich, Germany.

Science (New York, N.Y.)
|March 28, 2015
PubMed
Summary
This summary is machine-generated.

Researchers created 3D DNA structures that self-assemble without base pairing, forming complex objects like nanorobots and reconfigurable devices. These DNA assemblies are controlled by shape and environmental factors.

More Related Videos

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

23.0K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.3K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

23.0K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Area of Science:

  • * Nanotechnology
  • * Molecular Biology
  • * Materials Science

Background:

  • * DNA nanotechnology typically relies on base pairing for structure formation.
  • * Creating complex, non-biological 3D DNA assemblies remains a challenge.

Purpose of the Study:

  • * To demonstrate self-assembly of discrete 3D DNA components based on shape complementarity, independent of base pairing.
  • * To engineer reconfigurable DNA-based devices and structures.

Main Methods:

  • * Utilizing shape-complementarity for self-assembly of DNA components in solution.
  • * Employing electron microscopy, spectroscopy (FRET), and electrophoretic mobility analysis for characterization.
  • * Investigating control mechanisms including cation concentration, temperature, and strand-displacement reactions.

Main Results:

  • * Successful production of homo- and heteromultimeric DNA objects, including filaments, lattices, and functional devices.
  • * Demonstrated stabilization of assemblies through nucleobase stacking bonds counteracting electrostatic repulsion.
  • * Showcased fine control over assembly conformation via environmental parameters and allosteric mechanisms.

Conclusions:

  • * Shape-complementarity is a viable principle for programmable self-assembly of 3D DNA nanostructures.
  • * This approach enables the creation of sophisticated, reconfigurable DNA-based nanodevices.
  • * The findings open new avenues for designing complex molecular machines and materials using DNA.