Related Experiment Video
Updated: Apr 15, 2026

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
Published on: April 21, 2023
Gene expression profiles of the cochlea and vestibular endorgans: localization and function of genes causing deafness
Shin-Ya Nishio1, Mitsuru Hattori2, Hideaki Moteki2
1Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan.
Objectives:
We sought to elucidate the gene expression profiles of the causative genes as well as the localization of the encoded proteins involved in hereditary hearing loss.
Methods:
Relevant articles (as of September 2014) were searched in PubMed databases, and the gene symbols of the genes reported to be associated with deafness were located on the Hereditary Hearing Loss Homepage using localization, expression, and distribution as keywords.
Results:
Our review of the literature allowed us to systematize the gene expression profiles for genetic deafness in the inner ear, clarifying the unique functions and specific expression patterns of these genes in the cochlea and vestibular endorgans.
Conclusions:
The coordinated actions of various encoded molecules are essential for the normal development and maintenance of auditory and vestibular function.
Related Concept Videos
The Cochlea
Anatomy of the Ear
Auditory Pathway
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
Equilibrium and Balance
The Vestibular System
Hair Cells

