[Effect of the combined use of dextran sulfate and double-stranded RNA on interferon production]

The studies were performed on CBA mice. It was shown that polynucleotide inductors (poly I-poly C, RFf2 and poly G-poly C) stimulated production of interferon with a peak attained 4-6 or 24 hours after the induction. Intraperitoneal injection of dextran sulfate in a dose of 200 micrograms/m induced production of interferon in small amounts (80-120 units). The production peak was observed in 12 hours. The combined use of dextran sulfate and the polynucleotide inductors provoked an increase in the interferon production. The effect was of a synergistic nature. The cells of the immunocompetent system were the target of the dextran sulfate effect in the host, which was shown experimentally with a culture of mouse lymphocytes.