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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Related Experiment Video

Updated: Apr 15, 2026

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
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Modeling human nutrition using human embryonic stem cells.

Danny Ben-Zvi1, Douglas A Melton1

  • 1Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge MA, USA.

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|March 28, 2015
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Summary
This summary is machine-generated.

This study proposes advanced human stem cell models of the gut and metabolism, including gut microbes. These engineered systems will enable new research into nutrition and public health.

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Microbiology

Background:

  • Nutrition science faces complex, unanswered questions impacting public health.
  • Current research models have limitations in fully recapitulating human gastrointestinal and metabolic functions.

Purpose of the Study:

  • To develop novel, in vitro model systems for studying human nutrition.
  • To create a platform for investigating the interplay between diet, gut microbiota, and host metabolism.

Main Methods:

  • Utilizing human embryonic stem cells to derive gastrointestinal and metabolic tissues.
  • Incorporating gut microbiota into the engineered tissue models.
  • Embedding the co-cultures within 3D scaffolds for structural support and experimental access.

Main Results:

  • The development of a complex, multi-tissue model system.
  • A controlled environment for studying nutrient absorption and metabolic processes.
  • Facilitation of tissue sampling and advanced imaging techniques for detailed analysis.

Conclusions:

  • This novel stem cell-derived model system offers a powerful tool for advancing nutrition research.
  • The platform holds significant potential for addressing critical public health questions related to diet and disease.
  • Future studies can leverage this system to explore personalized nutrition and therapeutic interventions.