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Related Concept Videos

Overview of Myosin Structure and Function01:15

Overview of Myosin Structure and Function

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Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X)  have been well...
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The Sarcomere01:08

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A sarcomere is a microscopic segment repeating in a myofibril. The sarcomere fundamentally consists of two main myofilaments: thick filaments called myosin and thin filaments called actin. These filaments interact by sliding past each other in response to stimulus. In addition to myosin and actin, several other proteins, such as tropomyosin, troponin, titin, nebulin, myomesin, α-actinin, and dystrophin, play crucial roles in regulating, structuring, and functioning of the sarcomere.
Each...
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Cross-bridge Cycle01:26

Cross-bridge Cycle

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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

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Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
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Related Experiment Video

Updated: Apr 15, 2026

Probing Myosin Ensemble Mechanics in Actin Filament Bundles Using Optical Tweezers
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Probing Myosin Ensemble Mechanics in Actin Filament Bundles Using Optical Tweezers

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Myosin-X and disease.

David S Courson1, Richard E Cheney1

  • 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

Experimental Cell Research
|March 31, 2015
PubMed
Summary
This summary is machine-generated.

Myosin-X (Myo10), a motor protein, is increasingly linked to cancer metastasis and pathogen spread. Research shows Myo10 inhibition significantly reduces cancer cell motility and pathogen dissemination, highlighting its disease relevance.

Keywords:
CancerFilopodiaInfectious diseaseMetastasisMyo10Myosin-X

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X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Myosin-X (Myo10) is a motor protein primarily known for its function in filopodia formation.
  • Emerging evidence implicates Myo10 in significant disease states, including cancer metastasis and pathogen infection.

Purpose of the Study:

  • This review emphasizes the emerging roles of Myosin-X in the formation of cancer cell protrusions and metastasis.
  • It also explores the involvement of Myo10 in pathogen spread.

Main Methods:

  • Literature review focusing on recent research findings.
  • Analysis of studies investigating Myo10 expression levels in aggressive cancers.
  • Examination of experimental data on Myo10 knockdown effects in cancer cell models and pathogen infection systems.

Main Results:

  • High Myo10 expression correlates with aggressive cancers.
  • Myo10 knockdown significantly impairs cancer cell motility in both 2D and 3D environments.
  • Myo10 inhibition restricts the spread of intracellular pathogens like Marburg virus and Shigella flexneri.

Conclusions:

  • Myosin-X plays a critical role in cancer cell protrusion formation and metastasis.
  • Myo10 is implicated in the dissemination of specific intracellular pathogens.
  • Further research is warranted to understand the mechanisms underlying these roles and explore therapeutic potential.