Polysaccharide nanoparticles for protein and Peptide delivery: exploring less-known materials

Area of Science:

• Biomaterials Science
• Drug Delivery
• Nanotechnology

Background:

• The demand for effective protein and peptide drug delivery systems is increasing.
• Nanoparticles are promising carriers, with natural polysaccharides being particularly advantageous due to biodegradability, biocompatibility, and flexibility.
• Current research predominantly focuses on well-known polysaccharides like chitosan and hyaluronic acid.

Purpose of the Study:

• To review and explore the potential of underutilized polysaccharides as nanoparticle matrix materials for drug delivery.
• To highlight the properties and applications of these less-common polysaccharide-based nanoparticles.

Main Methods:

• Literature review of scientific databases.
• Analysis of properties (biodegradability, biocompatibility, structural flexibility) of various polysaccharides.
• Compilation of reported applications in nanoparticle formulation for drug delivery.

Main Results:

• Identified several under-explored polysaccharides with significant potential for nanoparticle development.
• Detailed the favorable characteristics of these materials for drug encapsulation and release.
• Summarized diverse applications, showcasing their versatility beyond common materials.

Conclusions:

• Less-explored polysaccharides represent a valuable resource for developing novel nanoparticle drug delivery systems.
• These materials offer unique advantages and can potentially overcome limitations associated with conventional polysaccharide carriers.
• Further research into these polysaccharides could lead to innovative therapeutic solutions.