Related Experiment Video

Updated: Apr 15, 2026

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

6.0K

A cluster of rotavirus enteritis in pediatric liver recipients

H Cui1, S Bai1, Z Huo1

  • 1The Center for Disease Control and Prevention of Xicheng District, Beijing, China.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|March 31, 2015
PubMed

Insights

A cluster of pediatric liver transplant patients experienced rotavirus-induced diarrhea. Genetic analysis revealed at least two distinct G9P[8] rotavirus strains, highlighting both community and hospital-acquired infections.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Transplant Medicine

Background:

  • Liver transplant recipients are immunocompromised, increasing susceptibility to infections.
  • Rotavirus is a common cause of gastroenteritis in children.

Purpose of the Study:

  • To investigate a rotavirus outbreak cluster in pediatric liver transplant recipients.
  • To characterize the rotavirus strains involved in the outbreak.

Main Methods:

  • Fecal samples from affected patients were tested for rotavirus using a Colloidal Gold Diagnostic Kit.
  • Rotavirus RNA was extracted, reverse transcribed, amplified, and sequenced.
  • Phylogenetic analysis was conducted using MEGA 6.06 software.

Main Results:

  • Four pediatric liver recipients developed diarrhea within five days.
  • Rotavirus was detected in all four patients' fecal samples.
  • Phylogenetic analysis identified at least two distinct G9P[8] rotavirus strains.
  • The outbreak involved both community-acquired and nosocomial infections.

Conclusions:

  • Rotavirus outbreaks can occur in vulnerable pediatric liver transplant populations.
  • Multiple rotavirus strains can co-circulate during an outbreak.
  • Infection control measures are crucial in transplant units to prevent nosocomial spread.
Keywords:
community infectionnosocomial infectionpediatric liver recipientsrotavirus enteritis

More Related Videos

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors19:02

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors

Published on: March 22, 2011

13.9K
Orthotopic Liver Transplantation in Rats18:25

Orthotopic Liver Transplantation in Rats

Published on: July 1, 2012

31.6K

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
63
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
765
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
596
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
861
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.4K