Evaluation of DXA vs. MRI for body composition measures in 1-month olds

D A Fields1, A M Teague1, K R Short1

  • 1CMRI Metabolic Research Program, the Harold Hamm Diabetes Center, Section of Endocrinology and Diabetes, Department of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.

Pediatric Obesity
|March 31, 2015
PubMed

Insights

Dual energy X-ray absorptiometry (DXA) is accurate for measuring total infant body composition, but magnetic resonance imaging (MRI) shows bias for trunk fat and fat-free mass estimates.

Area of Science:

  • Pediatric growth and development
  • Body composition analysis
  • Biomedical imaging techniques

Background:

  • Accurate infant body composition measurement is crucial for understanding early-life growth influences.
  • Genetics and environmental factors impact infant development.
  • Need for precise methods to assess body composition in infants.

Purpose of the Study:

  • To compare the accuracy and bias of body composition measurements in infants.
  • Evaluate dual energy X-ray absorptiometry (DXA) against magnetic resonance imaging (MRI).
  • Assess the reliability of different body composition depots.

Main Methods:

  • Dual energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) were employed.
  • Measured total and trunk fat mass (FM) and fat-free mass (FFM).
  • Study included 14 infants.

Main Results:

  • DXA and MRI showed no significant deviation from the line of identity for total FM and FFM.
  • Bland-Altman analysis indicated bias in trunk FM and trunk FFM measurements.
  • Regression analysis confirmed accuracy for total body composition.

Conclusions:

  • DXA is accurate and unbiased for estimating total infant fat mass and fat-free mass.
  • DXA demonstrates high agreement for total body composition.
  • DXA measurements for trunk fat mass and fat-free mass were found to be biased.
Abstract

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.5K
X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
11.1K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
370