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Updated: Apr 15, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Evaluation of DXA vs. MRI for body composition measures in 1-month olds
D A Fields1, A M Teague1, K R Short1
1CMRI Metabolic Research Program, the Harold Hamm Diabetes Center, Section of Endocrinology and Diabetes, Department of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Insights
Dual energy X-ray absorptiometry (DXA) is accurate for measuring total infant body composition, but magnetic resonance imaging (MRI) shows bias for trunk fat and fat-free mass estimates.
Area of Science:
- Pediatric growth and development
- Body composition analysis
- Biomedical imaging techniques
Background:
- Accurate infant body composition measurement is crucial for understanding early-life growth influences.
- Genetics and environmental factors impact infant development.
- Need for precise methods to assess body composition in infants.
Purpose of the Study:
- To compare the accuracy and bias of body composition measurements in infants.
- Evaluate dual energy X-ray absorptiometry (DXA) against magnetic resonance imaging (MRI).
- Assess the reliability of different body composition depots.
Main Methods:
- Dual energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) were employed.
- Measured total and trunk fat mass (FM) and fat-free mass (FFM).
- Study included 14 infants.
Main Results:
- DXA and MRI showed no significant deviation from the line of identity for total FM and FFM.
- Bland-Altman analysis indicated bias in trunk FM and trunk FFM measurements.
- Regression analysis confirmed accuracy for total body composition.
Conclusions:
- DXA is accurate and unbiased for estimating total infant fat mass and fat-free mass.
- DXA demonstrates high agreement for total body composition.
- DXA measurements for trunk fat mass and fat-free mass were found to be biased.
Background:
Detailed measures of infant body composition are needed for understanding the impact of genes and environment on growth early in life.
Objective:
The purpose of this study was to compare the accuracy and bias of body composition in infants.
Methods:
Dual energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) were used to determine body composition and the trunk depot. The depots measured were total fat mass (FM), total fat-free mass (FFM) and trunk FM and FFM using DXA and MRI in 14 infants.
Results:
None of the regression lines between DXA and MRI significantly deviate from the line of identity for any of the depots studied. However, Bland-Altman analyses revealed bias for trunk FM and trunk FFM.
Conclusion:
Our data showed DXA to be accurate (regression not significantly deviating from the line of identity), with high agreement (indicated by high R(2) ) and without bias (non-significant Bland-Altman) when estimating total FM and FFM. This could not be said for trunk estimates.
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