Related Experiment Video
Updated: Apr 15, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
[The role of E-cadherin cell adhesion molecule in human ontogenesis in norm and pathology]
Abstract:
E-cadherin is one of the most important cell adhesion molecules, which plays a key role in embryogenesis and adult tissues under normal conditions and during tumor development. Molecules of E-cadherin are located at the epitheliocyte surface and take part in the adhesion contacts formation which are a characteristic feature of epithelial tissues. The role of E-cadherin is not only in the maintenance of intercellular adhesion, but also in provision of cell proliferation and differentiation through participation in the realization of a number of signaling pathways, the main of which is the canonical Wnt signaling pathway. This review provides basic information regarding the role of E-cadherin in human ontogenesis in norm and pathology.
Related Concept Videos
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Structure of Cadherins
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Adherens Junctions
Adherens Junctions are Dynamic
Regulation of Angiogenesis and Blood Supply
Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...

